Building better brains with iron
نویسندگان
چکیده
Iron is a critical nutrient for brain development. Extremely low birth weight infants are at high risk because they deprived of iron transfer late in pregnancy. The Committee on Nutrition the American Academy Pediatrics recommends an intake least 2 mg/kg/day all preterm through 12 months age. deficiency that population exacerbated by rapid postnatal growth and blood loss phlebotomies. These deficits may be counterbalanced red cell transfusions; however, there concerns about overload transfused multiple times receiving enteral supplementation. In secondary analysis Preterm Erythropoietin Neuroprotection Trial, published this volume Journal, authors evaluated association with 60 90 days after supplementation was begun BSID=III scores 22 to 26 life. Guidelines were provided each center, but not mandated. status assessed using serum ferritin concentrations zinc protoporphyrin/heme ratio, doses adjusted as needed. A significant positive observed between BSID-III cognitive cumulative dose started. recommend starting oral supplements (4 mg/kg/day) 7 life if tolerating ml/kg/day feedings. sufficiency should estimated or ratio. Although results study intriguing, data represent post hoc randomized clinical trial. Numerous other variables have contributed better development increasing supplemental iron. It seems prudent follow recommendations until prospective trial completed. extremely ferritin; acute phase reactant values must interpreted caution evidence inflammation elevated CRP. Article page 102 ▸ Enteral Supplementation Infants Born its Positive Correlation Neurodevelopment; Post Hoc Analysis Trial Randomized Controlled TrialThe Journal PediatricsVol. 238PreviewTo test whether increased associated improved neurodevelopment Bayley Scales Infant Development, third edition (BSID-III) among enrolled (Epo) (PENUT). Full-Text PDF
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ژورنال
عنوان ژورنال: The Journal of Pediatrics
سال: 2021
ISSN: ['1085-8695', '0178-4919', '0022-3476', '1097-6833']
DOI: https://doi.org/10.1016/j.jpeds.2021.09.047